This tier list is influenced by personal opinions and experiences. Your preferences and gameplay style may differ, and that's perfectly fine. Use this guide as a reference to make informed decisions about which Uber bosses to target in Path of Exile.

• E Tier: Uber Sirus - Difficult and Not Recommended
• D Tier: Uber Cortex - Low Profit and Risky
• C Tier: Uber Elder of Worlds - Fast Farming with Risks
• B Tier: Uber Searing Xar - Fast Farming with Risks
• A Tier: Uber Elder - Profitable and Manageable
• A Tier: The Maven - Profitable and Manageable
• S Tier: Uber Shaper - Guaranteed Profit

↖ E Tier: Uber Sirus - Difficult and Not Recommended

• Profit: A profit of 120 poe divines with a relatively low investment.
• Key Drops: Threat of Hope, Watcher's Eye, other valuable items.

Uber Sirus is arguably the most challenging Uber boss, but the potential rewards are substantial. Threat of Hope drops alone can cover your costs, and other valuable items make it a profitable choice. Be prepared for a tough fight.

↖ D Tier: Uber Cortex - Low Profit and Risky

• Profit: Unfortunately, a loss of about 75 divines.
• Key Drops: Rare items with synthesized modifiers, Rational Doctrine Jewel.

Uber Cortex can be challenging due to map modifiers, and it has changed with fewer valuable drops. The synthesized items that were once a source of profit are no longer accessible. Consider this boss carefully, as it may result in losses.

↖ C Tier: Uber Elder of Worlds - Fast Farming with Risks

• Profit: Approximately 43 divines with a total investment of about 123 divines.
• Key Drops: Ashes of the Stars, Forbidden Flash, Forbidden Flame.

Uber Elder of Worlds is a high-risk, high-reward boss. While it can be extremely profitable due to rare drops like Ashes of the Stars, it's also quite a gamble. Speed clearing is excellent, making it a solid choice for fast farming, but be prepared for potential losses.

↖ B Tier: Uber Searing Xar - Fast Farming with Risks

• Profit: A profit of 76 divines with a similar investment to Uber Elder of Worlds.
• Key Drops: Omnics (e.g., Penesis Flask), Forbidden Flame, other valuable jewels.

Uber Searing Xar is comparable to Uber Elder of Worlds in terms of profitability and risk. It offers valuable jewel drops, making it slightly less of a gamble. Speed clearing is fast, but beware of potential losses.

↖ A Tier: Uber Elder - Profitable and Manageable

• Profit: A profit of 60 divines with a 60 divines investment.
• Key Drops: Watcher's Eye, Sublime Vision, other valuable items.

Uber Uber Elder offers profitable Watcher's Eye drops, making it worthwhile despite a moderate investment. It's a challenging fight but manageable if you're familiar with the mechanics. Consider this boss for both profit and a thrilling battle.

↖ A Tier: The Maven - Profitable and Manageable

• Profit: A 70 divines profit with a 130 divines investment.
• Key Drops: Awakened Gems, Elevated Sextants, Orb of Conflicts.

The Maven is a well-balanced boss for profit. It offers Awakened Gem drops and consistent income from Elevated Sextants and Orb of Conflicts. The fight itself is manageable, making it a solid choice for farming, despite not being the fastest.

↖ S Tier: Uber Shaper - Guaranteed Profit

• Profit: Approximately 150-160 chaos profit with a 34 divines investment.
• Key Drops: Sublime Vision, other valuable items.

Uber Shaper is a cost-effective boss to farm, offering a guaranteed profit. It may take a bit longer to clear, but valuable item drops make it a top choice for consistent income. It's relatively easy to handle.

In conclusion, the choice of which Uber boss to tackle depends on your risk tolerance, build, and preferences. Uber Shaper stands out as a safe and profitable option, while Uber Cortex is the riskiest with potential losses. Consider your strengths and goals when deciding which Uber boss to farm in Path of Exile.