Welcome to our in-depth guide on crafting a Perpetual Quicksilver Flask in Path of Exile (PoE) - a simple yet profitable venture for players at any level. This guide will take you through the process step by step, making it clear and effective.

• Step 1: Gathering Materials
• Step 2: Purchasing Instilling Orbs
• Step 3: Selecting Your Flask
• Step 4: Quality Enhancement
• Step 5: Setting Automatic Usage
• Step 6: Magic Transformation
• Step 7: The Rolling Process
• Step 8: Market Research
• Step 9: Repeat and Profit
• Step 10: Testing Your Flask
• Conclusion

↖ Step 1: Gathering Materials

First of all, you need Glassblower's Baubles that will enhance the quality of your flask up to 20%. The method can give more than this but we will stick to the basic 20% for simplicity reasons. Vendors also trade Baubles with quality flasks.

↖ Step 2: Purchasing Instilling Orbs

Instilling Orbs are important because they make the flask Perpetual. You can buy them from vendors if you do not have enough. Don't worry about the cost as they are cheap.

↖ Step 3: Selecting Your Flask

Go for two item level 85 Quicksilver Flasks. Such items are easily available in shops at a reasonable cost.

↖ Step 4: Quality Enhancement

Apply Glassblower's Baubles on your flasks until they reach 20% quality. This increases its duration.

↖ Step 5: Setting Automatic Usage

Configure your flasks to activate when charges are full using Instilling Orbs. This allows for Perpetual.

↖ Step 6: Magic Transformation

Change your flasks into magic items with Orbs of Transmutation. You want high tier rolls, those that greatly benefit the flask's use.

↖ Step 7: The Rolling Process

Use Alteration Orbs to roll mods for your flask. Look out for good prefixes and suffixes combination. Do not stop rolling low tier mods; be patient and keep trying until you get high-tier mods.

↖ Step 8: Market Research

After getting a desirable roll, check the market value of your crafted flask. This can be done by using tools such as PoE trade. Price your flask so that it sells quickly.

↖ Step 9: Repeat and Profit

Now you can start from where you ended when you put up your crafted flask for sale. The more you craft the better you will become at recognizing valuable mods leading to more profit.

↖ Step 10: Testing Your Flask

Lastly, test your in-game crafted flasks on the game. They should have the expected Perpetual. Make any adjustments depending on how they perform.

↖ Conclusion

Crafting a Perpetual Quicksilver Flask in PoE is not only straightforward but can also be quite profitable. You will master this art and improve both your play and in-game wallet if you are patient enough to practice it. Remember always to stick with it until it pays off in the saturation of market trends for the best results. Have fun crafting and may your flasks never get empty!